DNA methylation

DNA methylation

In addition to this flexible and dynamic module of the epigenome, which is associated with the genome but is not part of its covalent structure, the genome is covalently modified by addition of a methyl group at the 5th position of the cytosine ring. Since the methyl group is connected to DNA by a strong chemical bond, it is considered a stable and fixed mark. The vast majority of methylated cytosines in vertebrate genomes are found in the dinucleotide sequence CG. Not all CG dinucleotide...  { read more }

 Therapeutic implications

Therapeutic implications

Therapeutic implications of the epigenome on anticancer therapy

Inhibition of the main DNA methylation enzyme DNMT1 and the demethylase/ MBD2 results in a marked anticancer effect and has potential in anticancer therapy. We developed antisense and direct inhibitors of DNMT1 with demonstrated preclinical anticancer effect. A DNMT1 antisense molecule is currently in clinical trials (directed by MethylGene Inc.). Inhibition of MBD2/demethylase also showed anticancer activity in...  { read more }

 Cancer epigenetics

Cancer epigenetics

It is now clear that cancer is an epigenetic disease. In most tumors the DNA methylation pattern is defective. Vast regions of the genome lose their methylation while specific regions are heavily methylated.

Understanding the mechanisms that link chromatin structure and DNA methylation are extremely important for unraveling the possible mechanisms responsible for the DNA methylation pattern in normal tissues, possible physiological alterations of DNA methylation patterns throughout...  { read more }

 Epigenome

Epigenome

While genomic information is uniform in the different cells of complex organisms, the epigenome controls the differential expression of genes in specific cells. The programming of gene expression profiles is therefore dependent on the epigenome. The epigenome is composed of two modules, a component that is part of the covalent structure of DNA, methylated cytosines located in the dinucleotide sequence CG and a noncovalent module. Our understanding of the noncovalent module of the epigenome...  { read more }

News



New site

04/23/2012 (All day) | Szyf Lab - 1310 McIntyre Building - the Interweb

We are currently installing and designing our new website. Launch date: May 1, 2012.

It's going to be amazing, mind-blowing, too good to be true.

updated: 04/23/2012 - 17:39   |   comments(2)